has signed an  for the acquisition of all outstanding equity of TeneoTwo as well as its CD19/CD3 T-cell engager, TNB-486, in a deal worth up to $1.27bn to bolster the haematological cancer pipeline.

As per the deal, AstraZeneca will make an upfront payment of $100m on the closing of the transaction.

Furthermore, equity holders of TeneoTwo are entitled to get up to $805m in research and development (R&D)-based milestone payments as well as up to $360m as commercial-related milestone payments from AstraZeneca.

A Phase I clinical-stage asset, TNB-486 is being analysed for relapsed and refractory B-cell non-Hodgkin lymphoma.

It attaches to CD19, an antigen expressed on B-cells, and CD3 receptor on T-cells to stimulate and recruit T-cells to CD19-expressing tumours, where they can induce an immune response.

Through the acquisition of TNB-486, AstraZeneca intends to expedite the development of this new therapy for B-cell hematologic malignancies, including diffuse large B-cell lymphoma and follicular lymphoma. 

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Building on Calquence’s (acalabrutinib) success, TNB-486 is expected to further expand the haematology pipeline of AstraZeneca that covers various therapeutic modalities and mechanisms for addressing a wide range of blood cancers.

AstraZeneca Haematology R&D senior vice-president Anas Younes said: “By redirecting the body’s natural immune response to target B-cell malignancies, TNB-486 alone or in combination with CD20-targeted therapy could potentially deepen clinical responses and improve patient outcomes. 

“We believe this innovative molecule, which was designed to optimise the therapeutic window of T-cell activation, will enable us to explore novel combinations that have the potential to become new standards of care in this setting.�

Subject to necessary conditions and approvals, the deal is anticipated to conclude in the third quarter of this year.

Cell & Gene Therapy coverage on ÌìÃÀ´«Ã½app Technology is supported by Cytiva.

Editorial content is independently produced and follows the  of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.

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